Biomembrane-based organic electronic devices for ligand–receptor binding studies

by Han-Yuan Liu, Anna-Maria Pappa, Tania Cecilia Hidalgo, Sahika Inal, Rόisín M. Owens, Susan Daniel
Year: 2020

Bibliography

Biomembrane-based organic electronic devices for ligand–receptor binding studies
Han-Yuan Liu, Anna-Maria Pappa, Tania Cecilia Hidalgo, Sahika Inal, Rόisín M. Owens & Susan Daniel 
Analytical and Bioanalytical Chemistry, 2020

Abstract

We present a simple, rapid method for forming supported lipid bilayers on organic electronic devices composed of conducting polymer electrodes using a solvent-assisted lipid bilayer formation method. These supported bilayers present protein recognition elements that are mobile, critical for multivalent binding interactions. Because these polymers are transparent and conducting, we demonstrate, by optical and electrical detection, the specific interactions of proteins with these biomembrane-based bioelectronic devices. This work paves the way for easy formation of biomembrane mimetics for sensing and detection of binding events in a label-free manner on organic electronic devices of more sophisticated architectures.

                                                  

Keywords

Bioelectronics Biosensor PEDOT:PSS Protein recognition Supported lipid bilayers