Improving the compatibility of diketopyrrolopyrrole semiconducting polymers for biological interfacing by lysine attachment

by W. Du, D. Ohayon, C. Combe, L. Mottier, I.P. Maria, R.S. Ashraf, H. Fiumelli, S. Inal, I. McCulloch
Year:2018 DOI: DOI: 10.1021/acs.chemmater.8b02804

Bibliography

Improving the compatibility of diketopyrrolopyrrole semiconducting polymers for biological interfacing by lysine attachment
W. Du, D. Ohayon, C. Combe, L. Mottier, I.P. Maria, R.S. Ashraf, H. Fiumelli, S. Inal, I. McCulloch
Chemistry of Materials 30 (17), 6164-6172, 2018

Abstract

Pub_ICD_2018

 

Organic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged, and low-surface energy semiconducting thin films limits their use as part of in vitro, cell-integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole semiconducting polymer on neural cell adhesion and growth and evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need for biological coating steps while changing the surface physiochemistry, which makes them promising for applications in bioelectronics.

 
 


Keywords

Semiconducting films Biological applications Lysine side chains Semiconducting thin films
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